Open AccessModulation of P-selection and platelet aggregation in chronic periodontitis: A clinical study
Author(s) -
Ramesh Kannan Perumal,
Maheashwari Rajendran,
M. Krishnamurthy,
Kiran Kumar Ganji,
Sunil Pendor
Publication year - 2014
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.134563
Subject(s) - chronic periodontitis , medicine , platelet , periodontitis , p selectin , platelet activation , proinflammatory cytokine , bleeding on probing , tumor necrosis factor alpha , platelet membrane glycoprotein , c reactive protein , gastroenterology , immunology , inflammation
The primary etiologic factor of periodontitis is the subgingival infection with a group of Gram negative pathogens. Transient bacteremia in periodontitis patients underlie chronic production and systemic increases of various proinflammatory mediators, including Interleukin (IL)-1α, IL-6, C-reactive protein and Tumor necrosis factor (TNF)-α. P- selectin is a member of selectin family of cell surface receptor which is located in the membrane of the secretory granules (alpha granules) of platelets and in the membrane of the Weibel-Palade bodies of the vascular endothelial cells. P selectin redistributes from the membrane of the granules to the plasma membrane when platelets and endothelial cells are activated and thus degranulated.