Open AccessPeriodontal considerations in a patient with glucose-6-phosphate dehydrogenase deficiency with associated pancytopenia: A rare case report
Author(s) -
Harinder Gupta,
Ruchika Arora,
Monika Kamboj
Publication year - 2014
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.131334
Subject(s) - medicine , glucose 6 phosphate dehydrogenase deficiency , glucosephosphate dehydrogenase deficiency , pancytopenia , jaundice , asymptomatic , hemolysis , haemolysis , anemia , pediatrics , glucose 6 phosphate dehydrogenase , immunology , dehydrogenase , enzyme , bone marrow , biochemistry , chemistry
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme defect in humans. G6PD deficiency is widely distributed in tropical and subtropical parts of the world and a conservative estimate is that at least 500 million people have a G6PD deficient gene. In several of these areas, the frequency of a G6PD deficiency gene may be as high as 20% or more. The vast majority of people with G6PD deficiency remain clinically asymptomatic throughout their lifetime. However, all of them have an increased risk of developing neonatal jaundice and a risk of developing acute hemolytic anemia when challenged by a number of oxidative agents. The most important treatment measure is prevention: Avoidance of the drugs and foods that cause hemolysis.