Open AccessKinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study
Author(s) -
Ranganathan Vijayalashmi,
S Ravindranath,
N. D. Jayakumar,
Padmalatha,
Sheeja H Vargheese,
Kikkeri Laxminarayana Kumaraswamy
Publication year - 2013
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.118311
Subject(s) - porphyromonas gingivalis , tetracycline , microbiology and biotechnology , periodontitis , medicine , in vitro , chronic periodontitis , gingival and periodontal pocket , drug delivery , drug , pharmacology , antibiotics , chemistry , dentistry , biology , biochemistry , organic chemistry
Conventional anti-microbial therapy largely consisted of systemic administration of various drugs effective against periodontal pathogens, but fraught with several problems. Based on the concept of local drug delivery a bioresorbable device made of pure fibrillar collagen has been developed. The aim of this study was to study the release of Tetracycline from this collagen fiber (Type I collagen) impregnated with Tetracycline and its antibacterial activity against Porphyromonas gingivalis.