Biocompatibility and cytotoxic evaluation of drug‑loaded biodegradable guided tissue regeneration membranes | Zendy

Rajmohan Gopimohan | Zendy; NebuG Thomas | Zendy; GeorgeP Sanil | Zendy; JayachandranV Prabhakaran | Zendy; George Thomas | Zendy; Amulya K. Panda | Zendy

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Biocompatibility and cytotoxic evaluation of drug‑loaded biodegradable guided tissue regeneration membranes

Author(s) -

Rajmohan Gopimohan,

NebuG Thomas,

GeorgeP Sanil,

JayachandranV Prabhakaran,

George Thomas,

Amulya K. Panda

Publication year - 2012

Publication title -

journal of indian society of periodontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.309

H-Index - 28

eISSN - 0975-1580

pISSN - 0972-124X

DOI - 10.4103/0972-124x.106883

Subject(s) - biocompatibility , medicine , regeneration (biology) , membrane , drug , pharmacology , cytotoxic t cell , biomedical engineering , in vitro , microbiology and biotechnology , biochemistry , materials science , chemistry , metallurgy , biology

In periodontology, Guided Tissue Regeneration (GTR) is based on the concept of providing a space for entry of cells with regenerative potential into the wound environment to initiate the regeneration of structures lost due to periodontal disease. First generation GTR membranes were primarily non-absorbable membranes like expanded polytetrafluorethylene which required a second surgery for its removal. This led researchers to explore absorbable materials like collagen and synthetic biodegradable polymers to fabricate GTR membranes. In the present study, biodegradable Polylactic acid (PLA) is used to fabricate membranes with the potential to be used for GTR therapy.

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