Open AccessBiocompatibility and cytotoxic evaluation of drug‑loaded biodegradable guided tissue regeneration membranes
Author(s) -
Nebu George Thomas,
George P Sanil,
Rajmohan Gopimohan,
Jayachandran V Prabhakaran,
George Thomas,
Amulya K. Panda
Publication year - 2012
Publication title -
journal of indian society of periodontology (print)/journal of indian society of periodontology (online)
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.309
H-Index - 28
eISSN - 0975-1580
pISSN - 0972-124X
DOI - 10.4103/0972-124x.106883
Subject(s) - biocompatibility , medicine , regeneration (biology) , membrane , drug , pharmacology , cytotoxic t cell , biomedical engineering , in vitro , microbiology and biotechnology , biochemistry , materials science , chemistry , metallurgy , biology
In periodontology, Guided Tissue Regeneration (GTR) is based on the concept of providing a space for entry of cells with regenerative potential into the wound environment to initiate the regeneration of structures lost due to periodontal disease. First generation GTR membranes were primarily non-absorbable membranes like expanded polytetrafluorethylene which required a second surgery for its removal. This led researchers to explore absorbable materials like collagen and synthetic biodegradable polymers to fabricate GTR membranes. In the present study, biodegradable Polylactic acid (PLA) is used to fabricate membranes with the potential to be used for GTR therapy.