Open AccessComparison of levosimendan and nitroglycerine in patients undergoing coronary artery bypass graft surgery
Author(s) -
Manoj Kumar Sahu,
Anupam Das,
Vishwas Malik,
Arun Subramanian,
Sarvesh Pal Singh,
Milind Padmakar Hote
Publication year - 2016
Publication title -
annals of cardiac anaesthesia/annals of cardiac anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.42
H-Index - 27
eISSN - 0974-5181
pISSN - 0971-9784
DOI - 10.4103/0971-9784.173020
Subject(s) - levosimendan , medicine , intensive care unit , cardiac index , anesthesia , coronary artery bypass surgery , cardiology , cardiac surgery , potassium channel opener , hemodynamics , artery , cardiac output , inotrope , potassium channel
Levosimendan a calcium ion sensitizer improves both systolic and diastolic functions. This novel lusitropic drug has predictable antiischemic properties which are mediated via the opening of mitochondrial adenosine triphosphate-sensitive potassium channels. This action of levosimendan is beneficial in cardiac surgical patients as it improves myocardial contractility, decreases systemic vascular resistance (SVR), and increases cardiac index (CI) and is thought to be cardioprotective. We decided to study whether levosimendan has any impact on the outcomes such as the duration of ventilation, the length of Intensive Care Unit (ICU) stay, and the hospital stay when compared with the nitroglycerine (NTG), which is the current standard of care at our center.