Open AccessMethionine synthase polymorphisms (MTR 2756 A>G and MTR 2758 C>G) frequencies and distribution in the Jordanian population and their correlation with neural tube defects in the population of the northern part of Jordan
Author(s) -
Helmi Yousif Al Farra
Publication year - 2010
Publication title -
indian journal of human genetics
Language(s) - English
Resource type - Journals
eISSN - 0971-6866
pISSN - 1998-362X
DOI - 10.4103/0971-6866.73405
Subject(s) - methionine synthase , methionine , genotype , biology , population , microbiology and biotechnology , restriction fragment length polymorphism , allele , genetics , methylcobalamin , mtrr , allele frequency , methyltransferase , restriction enzyme , homocysteine , methylation , methylenetetrahydrofolate reductase , gene , biochemistry , vitamin b12 , medicine , amino acid , environmental health
The human methionine synthase gene (MTR) is located on chromosome 1q43; it is of 105.24 kb and is made up of 33 exons. Methionine synthase is a cytoplasmic enzyme that requires methylcobalamin for activity and catalyzes the remethylation of homocysteine to methionine. In this reaction, the methyl group of 5-methyltetrahydrofolate is transferred to the enzyme bond cob(I) alamin to generate methylcobalamin, followed by the transfer of the methyl group to homocysteine to reform methionine.