Methionine synthase polymorphisms (MTR 2756 A>G and MTR 2758 C>G) frequencies and distribution in the Jordanian population and their correlation with neural tube defects in the population of the northern part of Jordan | Zendy

HelmiYousif Al Farra | Zendy

Open Access

Methionine synthase polymorphisms (MTR 2756 A>G and MTR 2758 C>G) frequencies and distribution in the Jordanian population and their correlation with neural tube defects in the population of the northern part of Jordan

Author(s) -

HelmiYousif Al Farra

Publication year - 2010

Publication title -

indian journal of human genetics

Language(s) - English

Resource type - Journals

eISSN - 0971-6866

pISSN - 1998-362X

DOI - 10.4103/0971-6866.73405

Subject(s) - methionine synthase , methionine , genotype , biology , population , microbiology and biotechnology , restriction fragment length polymorphism , allele , genetics , methylcobalamin , mtrr , allele frequency , methyltransferase , restriction enzyme , homocysteine , methylation , methylenetetrahydrofolate reductase , gene , biochemistry , vitamin b12 , medicine , amino acid , environmental health

The human methionine synthase gene (MTR) is located on chromosome 1q43; it is of 105.24 kb and is made up of 33 exons. Methionine synthase is a cytoplasmic enzyme that requires methylcobalamin for activity and catalyzes the remethylation of homocysteine to methionine. In this reaction, the methyl group of 5-methyltetrahydrofolate is transferred to the enzyme bond cob(I) alamin to generate methylcobalamin, followed by the transfer of the methyl group to homocysteine to reform methionine.

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