Open AccessInvestigation of chromosomal aberrations in Egyptian hepatocellular carcinoma patients by fluorescence in situ hybridization
Author(s) -
Magda M. Aly,
Abeer A. Bahnassy,
Zekri N. Abdel-Rahman
Publication year - 2010
Publication title -
indian journal of human genetics
Language(s) - English
Resource type - Journals
eISSN - 0971-6866
pISSN - 1998-362X
DOI - 10.4103/0971-6866.69370
Subject(s) - hepatocellular carcinoma , fluorescence in situ hybridization , monosomy , biology , cytogenetics , cirrhosis , chromosome , karyotype , pathology , microbiology and biotechnology , cancer research , genetics , medicine , gene
Hepatocellular carcinoma (HCC) is a very common and highly malignant tumor, associated mainly with chronic viral hepatitis, cirrhosis of any cause, aflatoxin exposure and ethanol consumption. Cytogenetic analysis on HCC has been limited because of poor hepatocyte growth in vitro. Conventional cytogenetic studies have demonstrated frequent abnormalities of specific chromosomes in HCC. Molecular cytogenetic approaches have been applied only rarely in the characterization of HCC. The main aim of this study was to evaluate genetic aberrations of different chromosomes in HCC. The study included 35 patients with HCC, who have been diagnosed and treated at National Cancer Institute, Cairo University, Egypt. The clinico-pathologic features of the studied patient were collected from patient's files.