Open AccessAssociation of polymorphisms in leptin receptor gene with obesity and type 2 diabetes in the local population of Coimbatore
Author(s) -
Devi Murugesan,
Arunachalam Thirunavukkarasu,
Viraragavan Ramamurthy,
Selvi Subramanian
Publication year - 2010
Publication title -
indian journal of human genetics
Language(s) - English
Resource type - Journals
eISSN - 0971-6866
pISSN - 1998-362X
DOI - 10.4103/0971-6866.69350
Subject(s) - single nucleotide polymorphism , leptin receptor , candidate gene , obesity , type 2 diabetes , genetics , leptin , medicine , genotype , population , biology , endocrinology , polymorphism (computer science) , snp , body mass index , allele frequency , diabetes mellitus , gene , environmental health
Candidate gene association studies are very relevant to the area of clinical pharmacology. As information on candidate genes and candidate single nucleotide polymorphisms increases, a number of such candidates can be studied in a population to explore their association with their susceptible disease. One such attractive and popular Single Nucleotide Polymorphism (SNP) candidate for obesity is the gene coding for leptin receptor. The leptin receptor gene (LEPR) polymorphism plays an important role in obesity and type 2 diabetes. But the role of this polymorphism is not yet studied in Indian population. Hence, the study focused to explore the association of leptin receptor polymorphisms (K109R, Q223R and K656N) with obesity and type 2 diabetes in both diabetic and non-diabetic subjects recruited from the local population of Coimbatore.