Open AccessToxicological evaluation of pooled selected fractions of Mimosa invisa and protective effect of herbal decoction
Author(s) -
P.T.A. Usha,
N. Gopakumar,
AM Chandrasekhran Nair,
N. Divakaran Nair
Publication year - 2011
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.75873
Subject(s) - decoction , traditional medicine , aspartate transaminase , toxicity , creatinine , alkaline phosphatase , creatine kinase , tribulus terrestris , alanine transaminase , transaminase , kidney , urea , pharmacology , medicine , biology , biochemistry , enzyme , traditional chinese medicine , pathology , alternative medicine
The study was undertaken to evaluate the toxicity produced by the pooled selected fractions of Mimosa invisa in rabbits. An attempt was made to protect the animal from the toxicity using a decoction containing Hygrophila auriculata, Tribulus terrestris and Boerhaavia diffusa. Eighteen adult rabbits were divided into three groups of six animals each. Group I served as control. Group II received pooled fraction of M. invisa at 0.4 g/kg orally. Group III was administered with pooled fraction along with the decoction containing H. auriculata, T. terrestris and B. diffusa equivalent to 5 g/kg. The experiment was conducted for 20 days. Group II showed significant increase in biochemical parameters like alanine transaminase, aspartate transaminase, gamma glutamyl tranferase, creatine kinase, alkaline phosphatase, creatinine and urea, suggesting liver and kidney toxicity. Histopathological examination of the liver and kidney supported these findings. Heart also showed mild histopathological changes. Administration of decoction reversed the biochemical and histopathological changes, indicating the protective effect of decoction.