Open AccessIn Vitro anti-oxidant effect of vitamin E on oxidative stress induced due to pesticides in rat erythrocytes
Author(s) -
R. S. Saxena,
Poonam Garg,
DK Jain
Publication year - 2011
Publication title -
indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.75871
Subject(s) - chlorpyrifos , endosulfan , oxidative stress , antioxidant , vitamin e , lipid peroxidation , chemistry , toxicity , superoxide dismutase , glutathione , catalase , vitamin c , pesticide , vitamin , biochemistry , toxicology , food science , biology , enzyme , organic chemistry , agronomy
An attempt was made to study the antioxidant property of vitamin E in endosulfan and chlorpyrifos toxicity. Erythrocytes were collected from healthy rats and exposed to 1 ppm endosulfan and chlorpyrifos pesticides individually and also along with vitamin E treatment. Results showed that endosulfan was more toxic in comparison of chlorpyrifos. Activities of superoxide dismutase and catalase were significantly decreased, while lipid peroxidation and glutathione-S-transfarase were increased in comparison to the control values. The results of the present study suggest that vitamin E acts as an effective antioxidant for endosulfan and chlorpyrifos pesticide toxicity, in reducing oxidative stress burden.