Open AccessWater soluble fraction of diesel fuel induced histopathological alterations in the liver of Channa punctatus
Author(s) -
Preeti Handa Kakkar,
R. M. Saxena,
N S Rathee,
Mahesh C. Joshi
Publication year - 2011
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.75846
Subject(s) - hemolysis , diesel fuel , infiltration (hvac) , pathology , biology , chemistry , medicine , immunology , materials science , organic chemistry , composite material
The aim of this work was to verify the effects of water soluble fraction (WSF) of diesel fuel in liver of Channa punctatus. The fishes were exposed to sublethal concentration of WSF of diesel (5%-DF1, 10%-DF2, 15%-DF3, 20%-DF4 and 25%-DF5) for 21 days. Significant histopathological lesions observed were dilation, congestion, thrombosis formation in hepatoportal blood vessel, melanomacrophage centers, hemolysis, hemorrhage, lymphocytic infiltration between the hepatocytes and necrosis & fibrosis in hepatocytes were the prominent changes in liver. The histological analysis showed increasing damages dose-dependents and time-dependents.