Open AccessHaematolohical profile of subacute oral toxicity of molybdenum and ameliorative efficacy of copper salt in goats
Author(s) -
. Kusum,
Rajinder Raina,
Pawan Kumar Verma,
NK Pankaj,
Vinay Kant,
Jitender Kumar,
A. K. Srivastava
Publication year - 2010
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.72676
Subject(s) - mean corpuscular hemoglobin concentration , mean corpuscular volume , ammonium molybdate , hemoglobin , chemistry , mean corpuscular hemoglobin , erythrocyte sedimentation rate , toxicity , zoology , sodium molybdate , medicine , anemia , biochemistry , molybdate , biology , inorganic chemistry , raw material , organic chemistry
Molybdenum toxicity produces a state of secondary hypocuprosis, resulting into alterations in normal hematological profile. In the present study, ammonium molybdate alone and with copper sulfate (II) pentahydrate (ameliorative agent) was administered orally for 30 consecutive days in healthy goats of group 1 and 2, respectively, to access the effect on the hematological profile on different predetermined days of dosing. Administration of ammonium molybdate alone produced significant decline in the mean values of hemoglobin (Hb), packed cell volume (PCV), total leukocyte count (TLC), total erythrocyte count (TEC), and mean corpuscular hemoglobin concentration (MCHC), with a significant increase in neutrophil level and mean corpuscular volume (MCV). However, values of erythrocyte sedimentation rate, mean corpuscular hemoglobin, and differential leukocyte count were not significantly altered. On comparing observations of ameliorative group with the group 1 goats, it is concluded that the ameliorative copper salt has beneficial effects in alleviating the alterations in the values of Hb, PCV, TLC, TEC, MCV, MCHC, and neutrophils.