Open AccessAcetaminophen-induced Hepato- and Nephrotoxicity and Amelioration by silymarin and Terminalia chebula in rats
Author(s) -
KS Gopi,
A Gopala Reddy,
K Jyothi,
Anilkumar Banothu
Publication year - 2010
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.72672
Subject(s) - terminalia chebula , nephrotoxicity , blood urea nitrogen , creatinine , pharmacology , toxicity , acetaminophen , aspartate transaminase , oral administration , chemistry , urine , medicine , traditional medicine , alkaline phosphatase , biochemistry , enzyme
Experimental study was conducted to evaluate the hepato- and renoprotective effect of silymarin and Terminalia chebula against experimentally-induced acetaminophen (APAP) toxicity in rats. Oral administration of APAP @ 500 mg/kg for 1 to 3 days to all the four groups (six rats in each) resulted in significant elevation of serum triglycerides, total cholesterol, blood urea nitrogen, serum creatinine, and aspartate transaminase activity. Post-treatment with silymarin @ 25 mg/kg and T. chebula 125 mg/kg in groups 2 and 3 and their combination to group 4 from day 4 to 14 has significantly reversed the alterations of above said markers and offered better protection. The results of the study enunciated that silymarin and T. chebula exhibit good hepato- and nephro-protection against APAP toxicity.