Open AccessAcute high dose lithium-induced exacerbation of obsessive compulsive symptoms
Author(s) -
Shreekantiah Umesh,
Vinod Kumar Sinha
Publication year - 2014
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.139816
Subject(s) - exacerbation , serotonergic , lithium (medication) , obsessive compulsive , pathophysiology , medicine , sertraline , psychiatry , depression (economics) , psychology , anxiety , serotonin , antidepressant , receptor , macroeconomics , economics
Obsessive compulsive disorder (OCD) is a chronic neuropsychiatric disorder whose pathophysiology is linked to serotonergic dysfunction. More recently, the role of glutamate has also been posited. Lithium is used as an adjunctive for the treatment of OCD which is found to enhance serotonergic transmission. We present a case of OCD who was on stable dose of sertraline developed exacerbation of obsessive compulsive symptoms with acute high dose of lithium but improved after dose reduction.