Open AccessEvaluating the association between taqi variant of vitamin D receptor gene and susceptibility to tuberculosis: A meta-analysis
Author(s) -
Mohammed Y. Areeshi,
Raju K. Mandal,
Naseem Akhter,
Aditya K. Panda,
Shafiul Haque
Publication year - 2014
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.139791
Subject(s) - taqi , calcitriol receptor , meta analysis , odds ratio , medicine , confidence interval , vitamin d and neurology , genotype , gastroenterology , tuberculosis , genetic model , publication bias , polymorphism (computer science) , biology , genetics , gene , pathology
Vitamin D has been shown to hamper the growth of Mycobacterium tuberculosis in macrophages. The actions of vitamin D are exerted through a vitamin D receptor (VDR). The genetic variant TaqI of VDR has been implicated in tuberculosis (TB) risk in several case-control studies. However, these studies have shown inconsistent results. Hence, a meta-analysis was conducted to investigate the potential relationship between VDR TaqI polymorphism and risk of developing TB.