Open AccessSignificance of impaired serum gelatinases activities in metabolic syndrome
Author(s) -
Suraj Singh Yadav,
Manish Kumar Singh,
Pradeep Dwivedi,
Raju K. Mandal,
Kauser Usman,
Sanjay Khattri,
Kamlesh Kumar Pant
Publication year - 2014
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.128818
Subject(s) - matrix metalloproteinase , metabolic syndrome , pathogenesis , medicine , gelatinases , endocrinology , body mass index , diabetes mellitus , case control study , gelatinase
A consortium of metabolic risk factors accelerate the onset of diabetes, heart disease, stroke, and certain cancers. Proteolytic enzymes like matrix metalloproteinases (MMP) are regulated by a group of endogenous proteins called tissue inhibitors of metalloproteinases (TIMP). These TIMPs binds to active and alternate sites of activated MMPs and facilitate regulation. Impaired expression of MMPs may have a significant contribution in the pathogenesis of many tissues-destructive processes like tumor progression and cardiovascular and metabolic disorders.