Open AccessFurosemide and potassium chloride-induced alteration in protein profile of left ventricle and its associated risk for sudden cardiac death
Author(s) -
Ponniah Senthil Murugan,
Govindan Sadasivam Selvam
Publication year - 2014
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.128781
Subject(s) - furosemide , chemistry , potassium , ventricle , histopathology , potassium channel , pharmacology , proteomics , medicine , endocrinology , biochemistry , pathology , organic chemistry , gene
Potassium ion (K(+)) plays an essential role in maintaining the electrical potential across the plasma membrane of cells. An abnormal serum K(+) level is associated with increased risk of ventricular arrhythmia and sudden cardiac death (SCD) and these patients are generally prescribed with furosemide and potassium chloride (KCl). We explored the association between the use of these drugs and the risk of SCD by analyzing biochemical parameters and proteomic changes.