Open AccessPrognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning
Author(s) -
Shyam Chand Chaudhary,
Khemraj Singh,
Kamal Kumar Sawlani,
Nityanand Jain,
Arvind Kumar Vaish,
Virendra Atam,
Munna Lal Patel,
Avinash Kumar Ágarwal
Publication year - 2013
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.121669
Subject(s) - pralidoxime , atropine , medicine , organophosphate poisoning , anesthesia , emergency medicine , acetylcholinesterase , organophosphate , pesticide , biology , biochemistry , agronomy , enzyme
Organophosphorous (OP) poisoning is one of the most common poisonings seen in India. OP compounds act through inhibition of enzyme acetylcholinesterase and estimation of pseudocholinesterase (PCE) activity strengthens the diagnosis in clinically uncertain cases of OP poisoning. The role of pralidoxime (PAM) therapy in OP poisoning has been controversial.