Open AccessEvaluation of acute toxicity of pioglitazone in mice
Author(s) -
Pushpalatha Chinnam,
Mohammed Mohsin,
Leena M Shafee
Publication year - 2012
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.103660
Subject(s) - pioglitazone , medicine , rosiglitazone , toxicity , thiazolidinedione , endocrinology , pharmacology , insulin , diabetes mellitus , type 2 diabetes
The primary objective of the study is to assess the toxic effect of pioglitazone in mice. Pioglitazone belongs to thiazolidinedione group of oral antidiabetic agents. The earlier drug of this group troglitazone has been withdrawn due to its liver toxicity. The other drug rosiglitazone which was used like pioglitazone as insulin sensitizing agent in type 2 diabetes has been banned due to its cardiovascular side effects, recently. So, Pioglitazone was administered in high doses ¼ LD(50) and ½ LD(50) in mice to assess the acute toxic effect which also correlate with accidental over dose.