Open AccessA study on the toxic effects of doxorubicin on the histology of certain organs
Author(s) -
P. Shivakumar,
Munuswamy Usha Rani,
A Gopala Reddy,
Y. Anjaneyulu
Publication year - 2012
Publication title -
toxicology international/indian journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.129
H-Index - 26
eISSN - 0976-5131
pISSN - 0971-6580
DOI - 10.4103/0971-6580.103656
Subject(s) - doxorubicin , histology , kidney , medicine , endocrinology , vitamin e , vitamin , physiology , pathology , chemotherapy , chemistry , biochemistry , antioxidant
In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.