Open AccessRegulation of T cell lineage commitment by SMAR1 during inflammatory & autoimmune diseases
Author(s) -
Bhalchandra Mirlekar,
Subeer S. Majumdar,
Madhukar Khetmalas,
Samit Chattopadhyay
Publication year - 2015
Publication title -
indian journal of medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.578
H-Index - 87
ISSN - 0971-5916
DOI - 10.4103/0971-5916.169198
Subject(s) - proinflammatory cytokine , immune system , biology , t cell , microbiology and biotechnology , inflammation , immunology , rar related orphan receptor gamma , foxp3
CD4 + T cells are involved in abnormal inflammatory responses causing adverse effects to the body. Th17 cells play a major role in immune disorders and the exact mechanism by which CD4 + T cells regulate its effector Th1 and Th17 phenotype at chromatin level is not clearly understood. This study was aimed to understand the role of matrix associated region (MAR) binding protein SMAR1 (scaffold/matrix attachment region binding protein 1) in T cell differentiation during inflammatory and autoimmune condition using SMAR1 transgenic mice as model.