Open AccessSecondary acute myeloid leukemia after successful treatment for osteosarcoma
Author(s) -
Ravi Mittal,
Noorni V. Ramaswamy,
Ramesh Pandita,
Soad Al Bahar,
Nisreen Khalifa,
Souheïl Omar
Publication year - 2010
Publication title -
indian journal of medical and paediatric oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 0975-2129
pISSN - 0971-5851
DOI - 10.4103/0971-5851.68852
Subject(s) - medicine , leukocytosis , myeloid leukemia , osteosarcoma , cisplatin , chemotherapy , complication , amputation , leukemia , induction chemotherapy , surgery , myeloid sarcoma , sarcoma , oncology , cancer research , pathology
Secondary acute myeloid leukemia (sAML) is a rare complication following chemotherapy for osteogenic sarcoma. However, the exact offending drug is difficult to prove as there is no consistent data. It usually develops 2 years after completion of therapy. We report a case of sAML that developed within 8 months of completing the treatment. The patient was treated with cisplatin, doxorubicin and high-dose methotreaxate followed by surgery (amputation). Eight months after completion of therapy, while on follow-up, he presented with leukocytosis and thrombocytopenia and confirmed to have AML.