Open AccessComparison of vinorelbine with cisplatin in concomitant chemoradiotherapy in head and neck carcinoma
Author(s) -
Devleena,
Anup Majumdar,
Soumita Poddar,
Anindya Chakraborty
Publication year - 2010
Publication title -
indian journal of medical and paediatric oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 0975-2129
pISSN - 0971-5851
DOI - 10.4103/0971-5851.68845
Subject(s) - medicine , vinorelbine , head and neck cancer , radiosensitizer , mucositis , radiation therapy , concomitant , chemoradiotherapy , oncology , cancer , surgery , cisplatin , chemotherapy
Head and neck cancer is one of the most commonly occurring malignancies in the world. In India, the most commonly occurring head and neck cancers are those of the oral cavity and the pharynx. The majority of these cancers present with stage III/IV disease. Surgery and radiation therapy are the main treatment modalities. Concomitant chemoradiation is being investigated with the goal of improved local control that translates into improved survival. In this background, we have started this prospective randomized trial to ascertain the dose, schedule and sequence of therapy and to note whether Vinorelbine as radiosensitizer is equally effective as Cisplatin, comparing compliance, local control and toxicity.