Open AccessPalmar-plantar erythrodysesthesia: An uncommon adverse effect of everolimus
Author(s) -
Sunita Arora,
Akhil Rajendra,
Raju Titus Chacko,
Renu George
Publication year - 2016
Publication title -
indian journal of medical and paediatric oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 22
eISSN - 0975-2129
pISSN - 0971-5851
DOI - 10.4103/0971-5851.180143
Subject(s) - medicine , everolimus , adverse effect , rash , oncology , foot (prosody) , dermatology , philosophy , linguistics
Mammalian target of rapamycin inhibitor everolimus is a novel agent used in endocrine therapy resistant hormone receptor positive metastatic breast cancer. Its use has been associated with clinically significant improvement in the otherwise dismal outcomes of this subset of patients. Rash is a common adverse effect associated with everolimus. However, Hand-foot syndrome is an uncommon toxicity with the use of this drug. We report a case of Grade 3 hand-foot syndrome following institution of everolimus therapy and describe its successful management.