Open AccessANCA-associated Goodpasture′s syndrome in a patient with rheumatoid arthritis on penicillamine
Author(s) -
Rajesh Kumar Sharma,
Sahil Jain,
Vijay Kher
Publication year - 2012
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.83743
Subject(s) - medicine , penicillamine , rheumatoid arthritis , cyclophosphamide , goodpasture's syndrome , adverse effect , goodpasture syndrome , immunology , dermatology , gastroenterology , glomerulonephritis , kidney , chemotherapy , glomerular basement membrane
Although penicillamine has been used effectively in the management of a variety of diseases, several adverse reactions have been observed with prolonged administration of this agent. We report a case of Goodpasture's syndrome, as a result of induction of anti-myeloperoxidase antineutrophil cytoplasmic antibodies in a 51 year old man who was being treated with this drug for rheumatoid arthritis. This pulmonary-renal syndrome has been described on rare occasions in patients receiving penicillamine. Treatment with steroids and cyclophosphamide resulted in pulmonary and renal functional recovery.