Open AccessCollapsing glomerulopathy in an HIV-positive patient in a low-incidence belt
Author(s) -
I. Naaz,
Rayees ul Hamid Wani,
M Saleem Najar,
K A Banday,
Khalil Baba,
Humira Jeelani
Publication year - 2010
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.73451
Subject(s) - medicine , focal segmental glomerulosclerosis , glomerulopathy , membranoproliferative glomerulonephritis , nephropathy , proteinuria , pathology , glomerulonephritis , glomerulosclerosis , pathognomonic , incidence (geometry) , lupus nephritis , immunology , kidney , disease , diabetes mellitus , endocrinology , physics , optics
Human immunodeficiency virus (HIV) involves glomerular, tubulointerstitial, and vascular compartments of the kidney. The most common glomerular lesion is HIV-associated focal segmental glomerulosclerosis (FSGS) and related mesangiopathies collectively termed HIV-associated nephropathy (HIVAN). A variety of immune-complex mediated glomerular diseases such as membranoproliferative glomerulonephritis (MPGN), IgA nephropathy, and lupus-like glomerulonephritis also occur. HIVAN is restricted to patients presenting with proteinuria and progressive reduction of renal function and with distinctive but not pathognomonic pathology (FSGS often coexisting with glomerular collapse and tubular microcystic dilatations). The worldwide incidence of collapsing glomerulopathy (CG) in HIV-positive patients is high in Americans. But in India and other Asian countries, other forms of kidney diseases are more commonly seen. We report the first case of CG in the state of Jammu and Kashmir which also happens to be a very low incidence belt for HIV.