Open AccessEffectiveness of aminophylline prophylaxis of renal impairment after coronary angiography in patients with chronic renal insufficiency
Author(s) -
Atooshe Rohani
Publication year - 2010
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.65300
Subject(s) - medicine , aminophylline , creatinine , contrast induced nephropathy , blood urea nitrogen , incidence (geometry) , nephropathy , placebo , renal function , angioplasty , cardiology , urology , gastroenterology , anesthesia , endocrinology , pathology , physics , alternative medicine , optics , diabetes mellitus
This study was done to investigate whether aminophylline reduces the incidence of contrast induced nephropathy (CIN) after coronary angioplasty. Sixty patients who had serum creatinine concentration of > 1.3 mg/dl randomly received 250 mg IV aminophylline or placebo 30 minutes before coronary angiography. Serum creatinine and blood urea nitrogen were determined immediately before (base line) and at 24 and 48 hours after administration of contrast medium. The primary end point was the incidence of CIN. The incidence of CIN was 20% in placebo group and 13.3% in aminophylline group; older age was significantly associated with CIN: In this study, we could not demonstrate the prophylactic effect of a single infusion of 250 mg aminophylline, 30 minutes before administration of contrast media. A larger trial that incorporates the evaluation of clinically relevant outcomes is required to more adequately assess the role for aminophylline in CIN prevention.