Open AccessPrevalence of serum anti M-type phospholipase A2receptor antibody in primary membranous nephropathy: A single center experience
Author(s) -
Natarajan Gopalakrishnan,
P Abeesh,
Thanigachalam Dineshkumar,
S Murugananth,
Ramanathan Sakthirajan,
Gaurav Raman,
J Dhanapriya,
T Balasubramaniyan,
Haris Haris
Publication year - 2016
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.160334
Subject(s) - medicine , membranous nephropathy , proteinuria , gastroenterology , antibody , pathology , renal biopsy , nephropathy , single center , immunofluorescence , albumin , biopsy , immunology , endocrinology , kidney , diabetes mellitus
We conducted a prospective study to assess utility of detection of antibodies to phospholipase A2receptor (PLA2R) in the serum of patients with membranous nephropathy. Seventy five patients with biopsy proven membranous nephropathy admitted between January 2011 and September 2014 were studied. Serum anti- PLA2R was tested by indirect immunofluorescence. The test was positive in 45 out of 60 patients with primary membranous nephropathy (PMN) and in none of the 15 patients with secondary membranous nephropathy, with a sensitivity of 75% and specificity of 100% for PMN. Anti PLA2R positivity also showed a significant correlation with quantum of proteinuria and negative correlation with serum albumin. This study has validated detection of serum anti PLA2R in PMN as a non invasive diagnostic tool in Indian patients.