Open AccessIncidence and profile of C3 Glomerulopathy: A single center study
Author(s) -
Mohit Mathur,
Sanjeev Kumar Sharma,
Prasad Dharmendra,
Rajesh Kumar Garsa,
Abha Singh,
Rajesh Kumar,
Pankaj Beniwal,
Agarwal Dk,
Malhotra
Publication year - 2015
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.136889
Subject(s) - glomerulopathy , medicine , membranoproliferative glomerulonephritis , incidence (geometry) , renal biopsy , nephritic syndrome , pathology , renal function , single center , presentation (obstetrics) , biopsy , glomerulonephritis , retrospective cohort study , alternative complement pathway , gastroenterology , complement system , kidney , immunology , surgery , antibody , physics , optics
C3 glomerulopathy has recently been described as a distinct entity. The underlying mechanism is unregulated activation of the alternate pathway of the complement system. The most common presentation is with an acute nephritic syndrome. The diagnosis is made on immunofluoroscence by the presence of isolated or dominant C3 staining. In this retrospective study, renal biopsy data were collected from 2010 to 2013 patients with C3 glomerulopathy identified and their clinical and biochemical parameters analyzed. Out of 514 biopsies available for analysis, the incidence of C3 glomerulopathy was 1.16% (n = 6). The mean age of the presentation was 26 years and the average estimated glomerular filtration rate was 30.65 ml/min/1.73 m(2). The most common histopathological pattern was membranoproliferative glomerulonephritis (n = 4).