Open AccessMethemoglobinemia due to quinine causing severe acute kidney injury in a child
Author(s) -
S Kudale,
SK Sethi,
Maninder Dhaliwal,
Vijay Kher
Publication year - 2014
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.134681
Subject(s) - methemoglobinemia , medicine , primaquine , acute kidney injury , quinine , adverse effect , intensive care medicine , dapsone , pediatrics , pharmacology , malaria , anesthesia , dermatology , pathology , chloroquine
Congenital methemoglobinemia is a rare condition resulting from a deficiency of nicotinamide adenine dinucleotide-cytochrome b5 reductase. Acquired methemoglobinemia may result due to certain drugs, chemicals and food items. Information on epidemiological determinants from India is sparse. This report describes methemoglobinemia in a 4-year-old child after parenteral administration of quinine causing acute kidney injury. This case emphasizes the need of awareness of potential adverse events of antimalarial drugs. Prompt management of methemoglobinemia is essential to avoid potential life-threatening complications.