Open AccessMesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection
Author(s) -
Vivek Kute,
Aruna V Vanikar,
PR Shah,
Manoj R. Gumber,
Himanshu V. Patel,
Hargovind L Trivedi
Publication year - 2014
Publication title -
indian journal of nephrology/indian journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 24
eISSN - 1998-3662
pISSN - 0971-4065
DOI - 10.4103/0971-4065.127902
Subject(s) - medicine , acute kidney injury , nephritis , mesangial proliferative glomerulonephritis , interstitial nephritis , renal biopsy , glomerulonephritis , lupus nephritis , influenza a virus , pathology , kidney , immunology , biopsy , virus , disease
Respiratory complications and renal failure are the leading causes for morbidity and mortality due to influenza (H1N1) virus infection. There has been limited information on histopathology of H1N1 influenza-related acute kidney injury (AKI). We describe AKI with H1N1 infection in a 52-year-old female. Renal biopsy showed mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis. Her condition improved rapidly with oseltamivir, fluid replacement, steroid and dialysis. Our case suggests that H1N1 infection may have a causative link to the development of mesangial proliferative glomerulonephritis with acute tubulointerstitial nephritis.