Open AccessHemophagocytic syndrome secondary to cytomegalovirus infection in an infant
Author(s) -
Anshu Gupta,
Ruchira Sen,
Charu Batra,
D. P. K. Banerjee,
Anjali Gupta,
Medha Jain
Publication year - 2011
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.76949
Subject(s) - hemophagocytosis , pancytopenia , hepatosplenomegaly , medicine , histiocyte , cytomegalovirus , cervical lymphadenopathy , serology , pathology , immunology , lymph , biopsy , virology , virus , bone marrow , herpesviridae , viral disease , antibody , disease
Virus associated hemophagocytic syndrome is a non-neoplastic, generalized histiocytic proliferation with prominent hemophagocytosis associated with a systemic viral infection. We report a case of cytomegalovirus (CMV) associated hemophagocytic syndrome in a 2 month old male child presenting with rashes, fever, hepatosplenomegaly, cervical lymphadenopathy and pancytopenia. Fine needle aspiration cytology and biopsy from cervical lymph nodes revealed prominent hemophagocytosis. Serology for CMV IgM was positive in both the mother and the child, suggesting recent infection. Possibly there was intrauterine transmission of the infection.