Open AccessBax and Bak expression in cervical smears of women with low-and high-risk HPV types: A study of 120 cases
Author(s) -
Eirini Klapsinou,
Elena Argyri,
Efstathia Panotopoulou,
Dimitra Daskalopoulou,
Efstratios Patsouris,
Afroditi ni,
Andreas C. Lazaris,
Georgia-Eleni Thomopoulou
Publication year - 2015
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.171222
Subject(s) - medicine , staining , cervical cancer , stain , dysplasia , cervix , hpv infection , cervical intraepithelial neoplasia , immunohistochemistry , pathology , carcinogenesis , in situ hybridization , human papillomavirus , intraepithelial neoplasia , apoptosis , cancer , gene , biology , gene expression , genetics , prostate
Human papillomavirus (HPV) is known to be involved in the carcinogenesis of squamous cells in uterine cervix cancer, mostly by binding and inactivating the p53 and pRb tumor suppressor genes. Lately, evidence has emerged suggesting that HPV oncoproteins may interact with proteins involved in cellular apoptosis as well.