Open AccessGenotoxic and cytotoxic effects of X-ray on buccal epithelial cells following panoramic radiography: A pediatric study
Author(s) -
Poonam Agarwal,
Dhundanalli Puttalingaiah Vinuth,
Shashidevi Haranal,
Chandrashekar K Thippanna,
N Naresh,
Ganapathi Moger
Publication year - 2015
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.160559
Subject(s) - karyorrhexis , micronucleus test , medicine , ionizing radiation , micronucleus , radiography , buccal swab , buccal administration , nuclear medicine , pathology , radiology , biology , genetics , toxicity , dentistry , irradiation , apoptosis , physics , programmed cell death , nuclear physics
Ionizing radiation is a potent mutagenic agent capable of inducing both mutation and chromosomal aberrations. Non-lethal doses of ionizing radiation may induce genomic instability favoring carcinogenesis. In spite of their mutagenic potential, this kind of radiation is an important tool for diagnosis of the disease and is used in medical and dental practice. It has been believed that the number of micronucleus and increased frequency of other nuclear alterations, including karyorrhexis, condensed chromatin and pyknosis, are related to the increasing effects of carcinogens. Many approaches and techniques have been developed for the monitoring of human populations exposed to various mutagens, but the analysis of micronuclei (MN) has become a standard approach for the assessment of chromosomal damage in human populations.