Open AccessExtramedullary hematopoiesis as a ′clue′ to diagnosis of hepatoblastoma on fine needle aspiration cytology: A report of two cases
Author(s) -
Renu Thambi,
L Purnima Devi,
Krishna Balachandran,
Usha Poothiode
Publication year - 2013
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.117643
Subject(s) - hepatoblastoma , extramedullary hematopoiesis , medicine , cytology , differential diagnosis , fine needle aspiration , pathology , fine needle aspiration cytology , hepatocellular carcinoma , haematopoiesis , radiology , stem cell , biopsy , genetics , biology
Extramedullary hematopoiesis (EMH) evidenced by erythropoietic cells and megakaryocytes is a characteristic feature of hepatoblastoma (HB). The typical cytomorphology, the presence of EMH and associated clinical and radiological findings offer a reliable diagnosis of hepatoblastoma by fine-needle aspiration cytology (FNAC). We describe the cytologic features of hepatoblastomas and discuss the differential diagnosis in two children, aged 53 days and 19 years. The usefulness of EMH in differentiating HB from other small round cell tumors and well differentiated hepatocellular carcinoma (HCC) on cytology is highlighted.