Open AccessCytological diagnosis of Langerhans cell histiocytosis with cutaneous involvement
Author(s) -
Sushama A. Chandekar,
Vinaya B Shah,
Vikas Kavishwar
Publication year - 2013
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.107533
Subject(s) - langerhans cell histiocytosis , medicine , cytology , differential diagnosis , pathology , biopsy , presentation (obstetrics) , disease , medical diagnosis , histiocytosis , multisystem disease , dermatology , radiology
Langerhans cell histiocytosis (LCH) is a rare disease affecting predominantly children. The course of the disease varies, from spontaneous resolution to a progressive multisystem disorder with organ dysfunction and potential life-threatening complications. Diagnosis of LCH is often difficult and may be delayed because of its rarity and especially so if it occurs with unusual presentation. Fine needle aspiration cytology of a 4 year old male child, a case of LCH is presented with a purpose of highlighting the characteristic cytological features. A high index of suspicion, awareness of characteristic cytological features of LCH and its differential diagnoses is necessary. This can obviate the need of biopsy and electron microscopy. Immunohistochemistry if available can be performed on cytology smear and cell block.