Open AccessA case of pancreatic ductal adenocarcinoma with marked infiltration with IgG4-positive cells
Author(s) -
Misao Yoneda,
Hiroyasu Inada,
Kazuki Kanayama,
Taizo Shiraishi
Publication year - 2013
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.107513
Subject(s) - medicine , pathology , infiltration (hvac) , autoimmune pancreatitis , pancreatic cancer , pancreatitis , differential diagnosis , pancreas , fine needle aspiration , adenocarcinoma , ductal cells , pancreatic carcinoma , carcinoma , biopsy , cancer , immunohistochemistry , disease , physics , thermodynamics
A 75-year-old man was diagnosed as having pancreatic ductal carcinoma containing remarkable lymphocytic and plasma cell infiltration, as revealed by the cytological examination of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) specimen. The EUS-FNA specimen showed small amounts of atypical epithelium with noticeable lymphocytes and plasma cells. A pancreatic resection was performed, and the histopathological features showed an invasive pancreatic ductal carcinoma with autoimmune pancreatitis (AIP) lymphoplasmacytic sclerosing pancreatitis (LPSP)-like lesions. Most of the plasma cells were immunoreactive to anti-IgG4 antibody. EUS-FNA may be necessary for the differential diagnosis of AIP and pancreatic cancer, and close attention should be given to the presence of marked lymphoplasmacytic cells in EUS-FNA specimens while making the diagnosis.