Open AccessThe integration of HR-HPV increases the expression of cyclins A and E in cytologies with and without low-grade lesions
Author(s) -
Ma Isabel ZubillagaGuerrero,
Berenice IlladesAguiar,
Marco Antonio LeyvaVázquez,
Eugenia FloresAlfaro,
Eduardo Castañeda-Saucedo,
J.F. Muñoz-Valle,
L C Alarcón-Romero
Publication year - 2013
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.107504
Subject(s) - squamous intraepithelial lesion , cyclin , polymerase chain reaction , amplicon , cyclin e , cervical cancer , genotyping , microbiology and biotechnology , cyclin e1 , cell cycle , medicine , cyclin d , biology , pathology , cervical intraepithelial neoplasia , cancer , gene , genetics , genotype
Cyclin-A and cyclin-E are regulators of G1-S phase of normal cell cycle. Integration of human papilloma virus high-risk (HR-HPV) could alter this mechanism, and its overexpression has been associated with poor prognosis in cervical cancer.