Open AccessA comparative study for selectivity of micronuclei in oral exfoliated epithelial cells
Author(s) -
Sonal Grover,
Abr Mujib,
Abhishek Jahagirdar,
Neethu Telagi,
P Kulkarni
Publication year - 2012
Publication title -
journal of cytology/journal of cytology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.267
H-Index - 19
eISSN - 0974-5165
pISSN - 0970-9371
DOI - 10.4103/0970-9371.103940
Subject(s) - feulgen stain , stain , micronucleus test , pathology , papanicolaou stain , staining , micronucleus , medicine , h&e stain , cancer , cervical cancer , toxicity
Micronucleus (MN) represents small, additional nuclei formed by the exclusion of chromosome fragments or whole chromosomes lagging at mitosis. MN rates, therefore, indirectly reflect chromosome breakage or impairment of the mitotic apparatus. During the last few decades, micronuclei ("MNi") in oral exfoliated epithelial cells are widely used as biomarkers of chromosomal damage, genome instability and cancer risk in humans. However, until now only little attention has been given to the effect of different staining procedures on the results of these MN assays.