Open AccessImpaired neutrophil and monocyte chemotaxis in chronic and aggressive periodontitis and effects of periodontal therapy
Author(s) -
R Santhosh Kumar,
Shobha Prakash
Publication year - 2012
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.99042
Subject(s) - chronic periodontitis , medicine , periodontitis , aggressive periodontitis , statistical significance , chemotaxis , clinical significance , gastroenterology , dentistry , immunology , receptor
Depressed chemotactic activity of polymorphoneutrophil (PMN) and monocyte (MN) appears to be one of the significant risk factors in the development of periodontal disease. Although bacteria are the primary etiologic factor in periodontal disease, the patient's host response is a determinant of disease susceptibility. Depressed chemotaxis of PMN and MN could lead to periodontal destruction by altering the host response i.e. impairment of the normal host response in neutralizing infection and alterations that result in destruction of the surrounding periodontal tissues.