Open AccessOral lesions associated with hydroxyurea treatment
Author(s) -
Regina Maria Holanda de Mendonça,
Luiz Alcino Monteiro Gueiros,
Kátia Capellaro,
Vitória Régia Pereira Pinheiro,
Márcio Ajudarte Lopes
Publication year - 2011
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.94690
Subject(s) - medicine , adverse effect , dermatology , tongue , mucocutaneous zone , hydroxycarbamide , imatinib , immunosuppression , psoriasis , surgery , chemotherapy , pathology , disease , myeloid leukemia
Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate.