Open AccessExpression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: An immunohistochemical study
Author(s) -
M Thubashini,
Malathi Narasimhan,
Lakshminarayanan Kannan
Publication year - 2011
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.84299
Subject(s) - oral submucous fibrosis , immunohistochemistry , hsp70 , carcinogenesis , heat shock protein , pathology , medicine , oral mucosa , fibrosis , carcinoma , basal cell , cell , cancer research , biology , cancer , biochemistry , genetics , gene
Heat shock proteins are a highly conserved group of protective cellular proteins whose synthesis is increased in response to a variety of environmental or pathophysiological stresses. Heat shock proteins are useful biomarkers for carcinogenesis in tissues and signal the degree of differentiation and the aggressiveness of cancers. Regulation of heat shock protein 70 (HSP70) expression in oral submucous fibrosis is not known much, and the aim of this study was to evaluate HSP70 expression in oral submucous fibrosis and oral squamous cell carcinoma by immunohistochemical method and to understand the role of HSP70 in tumorigenesis.