Open AccessMorphological and ultrastructural characteristics of extracellular matrix changes in oral squamous cell carcinoma
Author(s) -
Usha Agrawal,
Himanshu Rai,
Arun K. Jain
Publication year - 2011
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.79968
Subject(s) - pathology , van gieson's stain , extracellular matrix , ultrastructure , chemistry , carcinoma , h&e stain , basophilic , metastasis , infiltration (hvac) , staining , medicine , cancer , materials science , biochemistry , composite material
The biology of oral squamous cell carcinoma (OSCC), including its progression from dysplasia to carcinoma, "field effects", genetic changes in tumor associated mucosa (TAM) and effect of matrix metalloproteinases in breaking down of matrix proteins to facilitate invasion, has been well documented. However, what remains to be done is to extrapolate this knowledge to improve patient care.