Open AccessEvaluation of telomerase expression in chronic periodontitis
Author(s) -
Thodur Madapusi Balaji,
Vettriselvi Venkatesan,
Solomon F.D. Paul,
Suresh Ranga Rao
Publication year - 2010
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.66632
Subject(s) - chronic periodontitis , telomerase , periodontitis , medicine , telomerase reverse transcriptase , inflammation , polymerase chain reaction , pathogenesis , reverse transcriptase , telomere , aggressive periodontitis , immunology , pathology , gene , biology , genetics
Human telomerase is a multi subunit ribonucleoprotein enzyme concerned with telomeric lengthening and homeostasis in man. This enzyme has been found to be elevated in inflammatory conditions like rheumatoid arthritis and silica injury lung. Since chronic periodontitis is also an inflammatory condition where immune cells and cytokines mediate tissue destruction, we set out to evaluate telomerase in gingival tissue samples from healthy subjects and chronic periodontitis patients by reverse transcriptase polymerase chain reaction.