Open AccessReverse transcriptase polymerase chain reaction study to evaluate dissemination of cancer cells into circulation after incision biopsy in oral squamous cell carcinoma
Author(s) -
Sunita N Dyavanagoudar,
Alka D Kale,
Kishore Bhat,
Seema Hallikerimath
Publication year - 2008
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.44534
Subject(s) - medicine , biopsy , cancer , micrometastasis , circulating tumor cell , pathology , cancer cell , cytokeratin , metastasis , polymerase chain reaction , reverse transcriptase , palpation , surgery , biology , immunohistochemistry , gene , biochemistry
Tissue manipulation by incisions, radiotherapy, and palpation may lead to dissemination of cancer cells into circulation. Circulating cancer cells in blood play a central role in metastatic process. Their numbers can be very small and for their detection,reverse transcriptase polymerase chain reaction (RT-PCR) has been successfully used in this study.