Open AccessPromoter hypermethylation patterns of P16, DAPK and MGMT in Oral Squamous Cell Carcinoma: A systematic review and meta-analysis
Author(s) -
K. R. Don,
Pratibha Ramani,
Vijayalakshmi Ramshankar,
Herald J Sherlin,
Priya Premkumar,
Anuja Natesan
Publication year - 2014
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.152208
Subject(s) - dna methylation , methylation , epigenetics , cancer research , medicine , methyltransferase , meta analysis , biomarker , oncology , cancer , basal cell , biology , gene , gene expression , genetics
Oral squamous cell carcinoma (OSCC) is a common cancer world-wide that is highly lethal due to its recurrence and metastasis. Methylation is a common epigenetic mechanism that leads to gene silencing in tumors and could be a useful biomarker in OSCC. The prevalence of P16, death-associated protein kinase (DAPK) and O6-methylguanine-DNA-methyltransferase (MGMT) promoter hypermethylation in OSCC has been evaluated for several years while the results remain controversial.