Promoter hypermethylation patterns of P16, DAPK and MGMT in Oral Squamous Cell Carcinoma: A systematic review and meta-analysis | Zendy

K. R. Don | Zendy; Pratibha Ramani | Zendy; Vijayalakshmi Ramshankar | Zendy; HeraldJustin Sherlin | Zendy; Priya Premkumar | Zendy; Anuja Natesan | Zendy

Open Access

Promoter hypermethylation patterns of P16, DAPK and MGMT in Oral Squamous Cell Carcinoma: A systematic review and meta-analysis

Author(s) -

K. R. Don,

Pratibha Ramani,

Vijayalakshmi Ramshankar,

HeraldJustin Sherlin,

Priya Premkumar,

Anuja Natesan

Publication year - 2014

Publication title -

indian journal of dental research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 43

eISSN - 1998-3603

pISSN - 0970-9290

DOI - 10.4103/0970-9290.152208

Subject(s) - dna methylation , methylation , epigenetics , cancer research , medicine , methyltransferase , meta analysis , biomarker , oncology , cancer , basal cell , biology , gene , gene expression , genetics

Oral squamous cell carcinoma (OSCC) is a common cancer world-wide that is highly lethal due to its recurrence and metastasis. Methylation is a common epigenetic mechanism that leads to gene silencing in tumors and could be a useful biomarker in OSCC. The prevalence of P16, death-associated protein kinase (DAPK) and O6-methylguanine-DNA-methyltransferase (MGMT) promoter hypermethylation in OSCC has been evaluated for several years while the results remain controversial.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research