Open AccessIn-silico analysis of heat shock protein 47 for identifying the novel therapeutic agents in the management of oral submucous fibrosis
Author(s) -
Jayasankar P Pillai,
Girish Parmar,
Rakesh Rawal,
Faraz Shaikh,
Girish Chauhan,
Rajarajeswari J Pillai
Publication year - 2014
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.147094
Subject(s) - in silico , virtual screening , docking (animal) , fibrosis , heat shock protein , chemistry , binding site , biochemistry , computational biology , medicine , biology , pathology , drug discovery , nursing , gene
Heat shock proteins-47 (HSP47) is a collagen specific molecular chaperone, involved in the processing and/or secretion of procollagen. It seems to be regularly upregulated in various fibrotic or collagen disorders. Hence, this protein can be a potential target for the treatment of various fibrotic diseases including oral submucous fibrosis (OSF), which is a collagen metabolic disorder of oral cavity and whose etiopathogeneic mechanism and therapeutic protocols are still not well documented.