In-silico analysis of heat shock protein 47 for identifying the novel therapeutic agents in the management of oral submucous fibrosis | Zendy

P. Jayasankar | Zendy; G Parmar | Zendy; Rakesh Rawal | Zendy; Faraz Shaikh | Zendy; GirishR Chauhan | Zendy; RajarajeswariJ Pillai | Zendy

Open Access

In-silico analysis of heat shock protein 47 for identifying the novel therapeutic agents in the management of oral submucous fibrosis

Author(s) -

P. Jayasankar,

G Parmar,

Rakesh Rawal,

Faraz Shaikh,

GirishR Chauhan,

RajarajeswariJ Pillai

Publication year - 2014

Publication title -

indian journal of dental research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.277

H-Index - 43

eISSN - 1998-3603

pISSN - 0970-9290

DOI - 10.4103/0970-9290.147094

Subject(s) - in silico , virtual screening , docking (animal) , fibrosis , heat shock protein , chemistry , binding site , biochemistry , computational biology , medicine , biology , pathology , drug discovery , nursing , gene

Heat shock proteins-47 (HSP47) is a collagen specific molecular chaperone, involved in the processing and/or secretion of procollagen. It seems to be regularly upregulated in various fibrotic or collagen disorders. Hence, this protein can be a potential target for the treatment of various fibrotic diseases including oral submucous fibrosis (OSF), which is a collagen metabolic disorder of oral cavity and whose etiopathogeneic mechanism and therapeutic protocols are still not well documented.

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