Open AccessImmunolocalization of heme oxygenase-1 in periodontal diseases
Author(s) -
GV Gayathri,
Subramanian Muthukumar,
Leena Dennis Joseph,
R Suresh
Publication year - 2014
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.147080
Subject(s) - heme oxygenase , heme , biliverdin , periodontitis , chronic periodontitis , context (archaeology) , chemistry , bilirubin , immunohistochemistry , oxygenase , medicine , pathology , biochemistry , enzyme , biology , paleontology
Chronic periodontitis is an inflammatory condition of supporting tissues initiated by organisms in dental plaque. The reactive oxygen species and free radicals mediate connective tissue destruction in periodontitis. In order to counteract the free radical mediated tissue damage, numerous antioxidant mechanisms exist within the host. One such system is heme oxygenase enzymes. Heme oxygenase is the key enzyme involved in catabolism of heme. It cleaves the heme molecule to yield equimolar amounts of biliverdin, carbon monoxide, and iron. These end products act as important scavengers of reactive oxygen metabolites. Increased heme oxygenase expression has been identified in inflammatory condition, such as pancreatitis, diabetes, nephritis, and atherosclerosis. Since chronic periodontitis is one such inflammatory condition, we assessed the expression of heme oxygenase-1, in smokers and periodontitis group using immunohistochemistry technique.