Open AccessExpression of maspin in benign and malignant salivary gland tumors: An immunohistochemical study
Author(s) -
V Reshma,
Kavita Rao,
N S Priya,
H S Umadevi,
T Smitha,
H S Sheethal
Publication year - 2014
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.138334
Subject(s) - maspin , myoepithelial cell , immunohistochemistry , salivary gland , pathology , mammary gland , cancer , medicine , cancer research , biology , breast cancer , metastasis
Maspin is a novel serine protease inhibitor (serpin) with multifaceted tumor-suppressive activities. It was originally identified in normal human breast myoepithelial cells and shows variable expression in different types of cancer cells. Maspin displays anti-metastatic properties in mammary and prostate cancer. Its expression is maintained during ovarian, lung and pancreatic carcinogenesis, indicating that Maspin regulated metastatic potential is tissue specific. Thus, it is possible that Maspin participates in salivary gland tumor biology as well. In this study, expression pattern of maspin in benign and malignant salivary gland tumors is analyzed, to understand the biological behavior of salivary gland tumors with respect to maspin expression.