Open AccessComparative analysis of gingival crevicular fluid neopterin levels in health and periodontal disease: A biochemical study
Author(s) -
Radhika Arjunkumar,
Uma Sudhakar,
P. Jayakumar,
Lalitha Tanjore Arunachalam,
Snophia Suresh,
Virupapuram Pramod
Publication year - 2013
Publication title -
indian journal of dental research/indian journal of dental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 43
eISSN - 1998-3603
pISSN - 0970-9290
DOI - 10.4103/0970-9290.123376
Subject(s) - neopterin , chronic periodontitis , medicine , gingivitis , periodontitis , group b , immunoassay , gastroenterology , dentistry , immunology , antibody
Periodontitis involves intricate interactions of the biofilm with the host immunoinflammatory response and subsequent alterations in bone and connective tissue homeostasis. Neopterin is a marker, belonging to the class of pteridines, which is associated with cell-mediated immunity. It is produced by interferon-γ stimulated macrophages. The levels of neopterin in body fluids are elevated in infections, autoimmune diseases, malignancies and allograft rejections. This investigation was designed to estimate the levels of neopterin in gingival crevicular fluid (GCF) in health, chronic gingivitis and chronic periodontitis.